Injury alert
On injured reserve
Source: NFL roster (via nflverse)
Is Isaac Guerendo playing this week?
Injured reserveIsaac Guerendo is on injured reserve, so is not available to play in the week 4 game against the Denver Broncos.
Kickoff: Sun, Oct 4 · 4:25 PM ET.
Checked Oct 3, 7:33 PM ET against the ESPN injury report and the NFL's official weekly report (via nflverse). Injury news can change up to kickoff, so confirm with the team close to game time.
Ask StatGrades about Isaac Guerendo
Ask your own questionOur numbers plus what they can't show: injuries around him, role changes, weather, rest and travel, line moves and the latest reporting, all linked.
Fantasy football · Week 4
Our own start/sit calls for every player, with a projected score, the range of likely outcomes and the reasons spelled out. Built from usage, matchup, Vegas lines and injuries. How we rank
Ruled out — find a replacement.
Why we say out
- On injured reserve.
- Averaged last season 0 carries and 0 targets a game.
- No. 4 RB on the depth chart.
Recent form
No games yet this season, so this projection rests on last season's 0.0 a game.
This week's matchup
- Expected team score
- ~25 pts
- Vegas line
- SF favored by 3
- Game total
- 47.5
- DEN vs RBs
- 7% fewer points
All week 4 running back rankings →Start or sit tool →How our past calls did →
Age
26
Height
6'0"
Weight
221 lb
College
Louisville; Wisconsin
Experience
2 seasons
Draft
2024 · Pick #129 (SF)
Status
RES
2026 Season Totals
Game log
Swipe sideways for all stats →
No graded games yet this season.